5/25/2025
Last update
5/25/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.7
USERS' SCORE
Good
Based on 2 Reviews
8.6
Top Medical Research Studies
4
We conducted a year-long study to investigate the effects of vitamin C on postoperative pain and recovery after a specific type of spine surgery known as posterior lumbar interbody fusion (PLIF). In this randomized, placebo-controlled trial, we worked with 123 patients, dividing them into two groups: one receiving vitamin C and the other a placebo.
Our main focus was to see how vitamin C influenced lower back pain measured by a visual analogue scale. While we found that there was no significant difference in pain levels at the one-year mark between the two groups, there was a silver lining. We observed that vitamin C appeared to enhance functional improvement, especially within the first three months after surgery.
So, while vitamin C didn’t seem to directly reduce pain intensity after surgery, it could play a role in supporting early recovery and everyday function. This finding may encourage further exploration into vitamin C's potential benefits in postoperative care for patients undergoing spine surgeries.
Our main focus was to see how vitamin C influenced lower back pain measured by a visual analogue scale. While we found that there was no significant difference in pain levels at the one-year mark between the two groups, there was a silver lining. We observed that vitamin C appeared to enhance functional improvement, especially within the first three months after surgery.
So, while vitamin C didn’t seem to directly reduce pain intensity after surgery, it could play a role in supporting early recovery and everyday function. This finding may encourage further exploration into vitamin C's potential benefits in postoperative care for patients undergoing spine surgeries.
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9
We investigated how a substance called HP influences iron-related oxidative stress and its connection to back pain in a common condition known as lumbar spinal stenosis (LSS). LSS causes significant discomfort and disability, particularly for older adults, primarily due to hypertrophy of the ligamentum flavum, which can be exacerbated by oxidative stress stemming from imbalanced iron levels.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
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5
We explored the connections between vitamin C levels in the blood and the occurrence of back pain, a common issue that impacts many adults. Drawing on data from the U.S. National Health and Nutrition Examination Survey (NHANES) conducted between 2003 and 2004, we focused on a substantial group of 4,742 participants aged 20 and above.
The study found that lower levels of serum vitamin C were linked to a higher prevalence of neck pain, low back pain, and even pain radiating below the knees. Specifically, the odds of experiencing neck pain increased by 50% and low back pain by 30% when vitamin C levels were suboptimal. Additionally, those with lower vitamin C levels were more likely to report conditions like arthritis and related functional limitations.
While these findings suggest a notable relationship between vitamin C and back pain, they do not establish a direct cause-and-effect link. As hypovitaminosis C appears more frequent in the population, further investigation is necessary to determine whether boosting vitamin C might be a beneficial approach for managing back pain effectively.
The study found that lower levels of serum vitamin C were linked to a higher prevalence of neck pain, low back pain, and even pain radiating below the knees. Specifically, the odds of experiencing neck pain increased by 50% and low back pain by 30% when vitamin C levels were suboptimal. Additionally, those with lower vitamin C levels were more likely to report conditions like arthritis and related functional limitations.
While these findings suggest a notable relationship between vitamin C and back pain, they do not establish a direct cause-and-effect link. As hypovitaminosis C appears more frequent in the population, further investigation is necessary to determine whether boosting vitamin C might be a beneficial approach for managing back pain effectively.
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Most Useful Reviews
10
New lease on life
4 people found this helpful
Miracle pill! I was diagnosed with anemia as a child, and taking my iron supplement was essential. I suffer from nerve damage in my lower back from surgery. After trying this new brand of iron, I felt incredible within 30 minutes—energetic and free from joint and lower back pain. A few days prior, walking had been difficult. It must be the combination of iron and vitamin C. I truly feel like a new person after taking this supplement.
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7.5
Increasing energy levels
1 people found this helpful
Only Iron I'll Take. I am borderline anemic, which affected my health clearance for physical volunteer work. I was sceptical about trying another iron pill due to past side effects but was convinced to try this by both my doctors. I've experienced mild constipation initially, but it resolved. Now, I feel energised in a way I never have before, allowing me to accomplish workouts that previously left me breathless and lightheaded, thanks to this iron.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.7
- All Researches
9
We set out to explore how iron treatment impacts back pain, particularly in the context of lumbar spinal stenosis (LSS). This condition, marked by the narrowing of the spinal canal, often leads to nerve compression and chronic inflammation—both linked to heightened iron levels in the body.
In our study, we examined the effects of melittin, a component derived from bee venom, on iron metabolism and macrophage activity in rats suffering from LSS. By treating macrophages with melittin, we found that it promoted a shift toward M2 polarization, which is associated with healing and repair, especially in the presence of excessive iron.
Notably, we observed that melittin not only improved the locomotor recovery of the rats but also facilitated axonal growth. However, it’s crucial to mention that while melittin showed benefits in managing inflammation and promoting repair processes, the study did not isolate the direct impact of iron treatment on pain relief itself. This means we cannot conclusively state that iron treatment alone would yield significant results for back pain without the influence of melittin.
Overall, melittin appears to hold promise for supporting spinal health by regulating iron levels and modifying macrophage behavior, thereby enhancing recovery outcomes in models of LSS.
In our study, we examined the effects of melittin, a component derived from bee venom, on iron metabolism and macrophage activity in rats suffering from LSS. By treating macrophages with melittin, we found that it promoted a shift toward M2 polarization, which is associated with healing and repair, especially in the presence of excessive iron.
Notably, we observed that melittin not only improved the locomotor recovery of the rats but also facilitated axonal growth. However, it’s crucial to mention that while melittin showed benefits in managing inflammation and promoting repair processes, the study did not isolate the direct impact of iron treatment on pain relief itself. This means we cannot conclusively state that iron treatment alone would yield significant results for back pain without the influence of melittin.
Overall, melittin appears to hold promise for supporting spinal health by regulating iron levels and modifying macrophage behavior, thereby enhancing recovery outcomes in models of LSS.
Read More
9
We investigated how a substance called HP influences iron-related oxidative stress and its connection to back pain in a common condition known as lumbar spinal stenosis (LSS). LSS causes significant discomfort and disability, particularly for older adults, primarily due to hypertrophy of the ligamentum flavum, which can be exacerbated by oxidative stress stemming from imbalanced iron levels.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Read More
8
We examined how Vitamin C, when combined with other supplements, could help manage chronic low back pain (LBP), especially in patients dealing with lumbar osteoarthritis. In our study, we divided sixty participants into two groups: one that received physical therapy alone and another that combined this therapy with a daily intake of Fortigel® and additional nutrients like Vitamin C, sodium hyaluronate, manganese, and copper.
Over the treatment period, we assessed the participants' pain levels, disability, and overall quality of life at three different times: at the start of the study, at the end of the initial treatment, and about a month later.
The results suggested that the group taking the additional supplements experienced significant improvements in pain relief and rehabilitation benefits compared to those who relied solely on exercise. However, since Vitamin C was part of a combination with other nutrients, its individual impact on back pain remains unclear. Thus, while overall results are promising, the specific benefit of Vitamin C in isolation can't be stated with certainty.
Over the treatment period, we assessed the participants' pain levels, disability, and overall quality of life at three different times: at the start of the study, at the end of the initial treatment, and about a month later.
The results suggested that the group taking the additional supplements experienced significant improvements in pain relief and rehabilitation benefits compared to those who relied solely on exercise. However, since Vitamin C was part of a combination with other nutrients, its individual impact on back pain remains unclear. Thus, while overall results are promising, the specific benefit of Vitamin C in isolation can't be stated with certainty.
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8
Chitogel with Deferiprone aids recovery
We explored the potential of a Chitogel and Deferiprone mixture in preventing harmful scarring after spinal surgery. In this study, fifteen sheep underwent laminectomy, a common spinal procedure, and were treated with various gels, including a control group without treatment.
After three months, we evaluated the outcomes using MRI and tissue examination. The results showed that the combination of Chitogel with Deferiprone at 20 mM was not only safe but also effectively reduced inflammation and the formation of adhesions. This suggests a promising approach to improving post-surgery recovery in patients.
After three months, we evaluated the outcomes using MRI and tissue examination. The results showed that the combination of Chitogel with Deferiprone at 20 mM was not only safe but also effectively reduced inflammation and the formation of adhesions. This suggests a promising approach to improving post-surgery recovery in patients.
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8
We aimed to understand if alkaline mineral supplementation could alleviate low back pain. In our open study, 82 participants took a lactose-based alkaline multimineral supplement for four weeks alongside their regular medications. Remarkably, pain scores dropped by 49%, and 76 out of 82 patients experienced relief.
We noted significant increases in blood buffering capacity and pH, suggesting that an acid-base imbalance could play a role in back pain. However, minerals like iron did not show significant changes. Ultimately, this simple supplement appears to greatly help those suffering from chronic low back pain.
We noted significant increases in blood buffering capacity and pH, suggesting that an acid-base imbalance could play a role in back pain. However, minerals like iron did not show significant changes. Ultimately, this simple supplement appears to greatly help those suffering from chronic low back pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
New lease on life
4 people found this helpful
Miracle pill! I was diagnosed with anemia as a child, and taking my iron supplement was essential. I suffer from nerve damage in my lower back from surgery. After trying this new brand of iron, I felt incredible within 30 minutes—energetic and free from joint and lower back pain. A few days prior, walking had been difficult. It must be the combination of iron and vitamin C. I truly feel like a new person after taking this supplement.
Read More
7.5
Increasing energy levels
1 people found this helpful
Only Iron I'll Take. I am borderline anemic, which affected my health clearance for physical volunteer work. I was sceptical about trying another iron pill due to past side effects but was convinced to try this by both my doctors. I've experienced mild constipation initially, but it resolved. Now, I feel energised in a way I never have before, allowing me to accomplish workouts that previously left me breathless and lightheaded, thanks to this iron.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Farì G, Santagati D, Pignatelli G, Scacco V, Renna D, et al. Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back Pain. Endocr Metab Immune Disord Drug Targets. 2022;22:108. 10.2174/1871530321666210210153619
- Lee GW, Yang HS, Yeom JS, Ahn MW. The Efficacy of Vitamin C on Postoperative Outcomes after Posterior Lumbar Interbody Fusion: A Randomized, Placebo-Controlled Trial. Clin Orthop Surg. 2017;9:317. 10.4055/cios.2017.9.3.317
- Dionne CE, Laurin D, Desrosiers T, Abdous B, Le Sage N, et al. Serum vitamin C and spinal pain: a nationwide study. Pain. 2016;157:2527. 10.1097/j.pain.0000000000000671
- Ahmed S, Shah Z, Ali N. Chronic low backache and stiffness may not be due ankylosing spondylitis. J Pak Med Assoc. 2010;60:681.
- Kim H, Hong JY, Jeon WJ, Lee J, Lee YJ, et al. Melittin regulates iron homeostasis and mediates macrophage polarization in rats with lumbar spinal stenosis. Biomed Pharmacother. 2022;156:113776. 10.1016/j.biopha.2022.113776
- Hong JY, Kim H, Lee J, Jeon WJ, Lee YJ, et al. Inhibits Iron Overload-Induced Oxidative Stress through Activation of Signaling in a Rat Model of Lumbar Spinal Stenosis. Oxid Med Cell Longev. 2022;2022:3472443. 10.1155/2022/3472443
- Vediappan RS, Mascarenhas A, Nguyen-Hoang A, Anne Fong S, Jukes A, et al. Prevention of peridural adhesions in spinal surgery: Assessing safety and efficacy of Chitogel with Deferiprone in a sheep model. J Clin Neurosci. 2020;72:378. 10.1016/j.jocn.2019.12.042
- Dyszkiewicz AJ, Kępiński P, Połeć P, Chachulski D, Nowak-Kostrzewska E. Changeability of tissue's magnetic remanence after galvanic-magnetostimulation in upper-back pain treatment. Comput Biol Med. 2015;66:242. 10.1016/j.compbiomed.2015.08.009
- Vormann J, Worlitschek M, Goedecke T, Silver B. Supplementation with alkaline minerals reduces symptoms in patients with chronic low back pain. J Trace Elem Med Biol. 2001;15:179.
